Equipe

Leonardo Luis Fruttero

Posição: Researcher abroad - present collaboration

Email: leonardofruttero@gmail.com

Vínculo Profissional:

Assistant professor of the Universidad Nacional de Cordoba, Argentina

Researcher of CONICET

Linhas de Pesquisa:
Jaburetox and Soyuretox
Neurotoxicity of ureases and derived peptides
Ureases - non-catalytic properties

Formação Acadêmica:

Ph.D,:
Chemical Sciences (2011 – Univ. Nacional de Córdoba, Argentina) –supervision: Lílian Canavoso

Post-doctoral fellow of the Young Talent Program, CNPq – Science without Borders Program, at LaNeurotox, PUCRS (2014-2017).

Objetivos:

– Studies of the neurotoxicity of Jaburetox in insects, particularly aiming to understand how the peptide affects the enzymes nitric oxide synthase and  UDP-N-acetylglucosamine pyrophosphorylase in Rhodnius prolixus and Nauphoeta cinerea

Currículo: http://lattes.cnpq.br/6043903192486126

Vida no Laboratório:

Collaboration with LaNeurotox/Laprotox started in 2011

Young Scientist Award 2015 – International Union of Biochemistry and Molecular Biology (IUBMB)

 

Publications

Fruttero, L. L.; Moyetta, N. R.; Krug, M. S.; Broll, V.; Grahl, M.V.C.; Real-Guerra, R.; Stanisçuaski, F.; Carlini, C. R. Jaburetox affects gene expression and enzyme activities in Rhodnius prolixus, a Chagas’ disease vector. Acta Tropica, v.168, p.54 – 63, 2017.

Moyetta, N. R.; Broll, V.; Perin, A.P.A.; Uberti, A. F.; Grahl, M.V.C.; Stanisçuaski, F.; Carlini, C. R.; Fruttero, L.L. Jaburetox-induced toxic effects on the hemocytes of  Rhodnius prolixus  (Hemiptera: Reduviidae). Comparative Biochemistry And Physiology C-Toxicology & Pharmacology, v.200, p.17-26, 2017.

Broll, V.; Martinelli, A.H.S.; Lopes, F. C.; Fruttero, L. L.; Zambelli, B.; Salladini, E.; Dobrovolska, O.; Ciurli, S.; Carlini, C. R.  Structural analysis of the interaction between Jaburetox, an intrinsically disordered protein, and membrane models. Colloids and Surfaces B-Biointerfaces. , v.159, p.849 – 860, 2017.

Fruttero, L. L.; Moyetta, N. R.; Uberti, A. F.; Grahl, M.V.C.; Lopes, F. C.; Broll, V.; Feder, D.; Carlini, C. R. Humoral and cellular immune responses induced by the urease-derived peptide Jaburetox in the model organism Rhodnius prolixus. Parasites & Vectors, v.9, p.412 – 426, 2016.

Martinelli, A.H.S.; Lopes, F. C.; Broll, V.; Defferrari, M. S.; Ligabue-Braun, R.; Kappaun, K.; Tichota, D. M.; Fruttero, L. L.; Moyetta, N. R.; Demartini, D. R.; Postal, M.; Medeiros-Silva, M.; Becker-Ritt, A. B.; Pasquali, G.; Carlini, C. R. Soybean ubiquitous urease with purification facilitator: An addition to the moonlighting studies toolbox. Process Biochemistry (1991), v.53, p.245 – 258, 2016.

Galvani, G. L.; Fruttero, L. L.; Coronel, M. F.; Nowicki, S.; Demartini, D. R.; Defferrari, M. S.; Postal, M.; Canavoso, L. E.; Carlini, C. R.; Settembrini, B. P.  Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera). Biochimica et Biophysica Acta-General Subjects, v.1850, p.255 – 262, 2014

(see also “Other Productions“)

Orientação Conjunta: